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KMID : 0615720140310010051
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Jouranl of Korean Acupuncture and Moxibustion society
2014 Volume.31 No. 1 p.51 ~ p.60
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The Effect of Alismatis Rhizoma Herbal-acupuncture at KI10 on LPS-induced Nephritis in Rats
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Han Je-Geun
Kim Yang-Seob
Kim Byung-Soo
Yim Yun-Kyoung
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Abstract
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Objectives : This study aimed to evaluate the effects of Alismatis Rhizoma Herbal-acupuncture(AR-HA) at KI10(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rat.
Methods : Rats were injected with LPS to induce nephritis. The rats in KI10-AR-HA group were treated with AR-HA, KI10-NP group with needle prick, KI10-saline group with normal saline injection respectively at KI10 three times for a week. Several experimental items were performed including measurements of the numbers of RBC, WBC, neutrophil in blood, the levels of creatinine, TNF-α, CINC-1 in serum, creatinine, total protein in urine, MPO in kidney.
Results : Needle prick stimulation at KI10 significantly reduced WBC in blood of LPS-stimulated rats. Saline injection at KI10 significantly reduced WBC in blood, TNF-α in serum, total protein in urine of LPS-stimulated rats. AR-HA at KI10 significantly reduced WBC, neutrophil in blood, TNF-α, CINC-1 in serum, creatinine, total protein in urine of LPS-stimulated rats.
Conclusion : AR-HA at KI10 has a therapeutic effect on nephritis in LPS-stimulated rat. There may be a synergism between KI10(Umgok) stimulation and AR-HA solution.
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KEYWORD
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Nephritis, Herbal-acupuncture, KI10, Alismatis Rhizoma
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